52 side effects

Side effect	Frequency	PubMed Central	MedlinePlus	Drugs.com	Mayo Clinic	WebMD	GoodRx	Healio.com	Poison.org	My.clevelandclinic.org	Oacapps.med.jhmi.edu
Nausea	common	—	nausea	Nausea	nausea	nausea	nausea	Nausea	nausea	—	nausea
Headache	common	—	headache	Headache	headache	—	Headache	Headache disorder	—	—	headache
Dizziness	—	—	dizziness	dizziness	dizziness	—	Dizziness	Dizziness	dizziness	—	dizziness
Nervousness	very rare	—	nervousness	Nervousness	nervousness	—	Nervousness or anxiety	Nervousness	—	—	nervousness
Rebound Congestion	common	—	rebound congestion	—	—	rebound congestion	rebound congestion	Rebound congestion	—	Worsening runny or stuffy nose	rebound congestion/hyperemia
Burning	—	—	burning	Burning	Burning	burning	Nasal stinging or burning	—	burning or stinging sensation	—	transient burning
Stinging	—	—	stinging	stinging	stinging	stinging	Nasal stinging or burning	stinging	burning or stinging sensation	—	stinging
Sneezing	common	—	sneezing	Sneezing	sneezing	sneezing	Sneezing	Sneezing	sneezing	Sneezing	sneezing
Runny Nose	common	—	increased nasal discharge	increase in runny or stuffy nose	increase in runny or stuffy nose	runny nose	Runny nose	increased runny nose	nasal congestion	Worsening runny or stuffy nose	—
Dryness	common	—	dryness inside the nose	Dryness	dryness	—	Nasal dryness	Dry nose	—	Dryness or irritation inside the nose	—
High Blood Pressure	—	—	—	high blood pressure	high blood pressure	—	Raised blood pressure	Hypertension	—	—	hypertension
Fast Heartbeat	rare	—	fast heartbeat	fast, irregular, or pounding heartbeat	fast, irregular, or pounding heartbeat	—	Raised heart rate	Palpitations	—	—	—
Slow Heartbeat	—	—	slow heartbeat	—	—	—	slow heart rate	—	slow heart rate	—	—
Tremor	—	—	—	trembling	trembling	—	—	Tremor	—	—	tremor
Insomnia	rare	—	difficulty falling asleep or staying asleep	trouble in sleeping	trouble in sleeping	—	trouble sleeping	Insomnia	—	—	—
Anxiety	rare	—	—	Anxiety	—	—	Anxiety	—	—	—	—
Irritability	very rare	—	—	Irritability	—	—	—	—	—	—	—
Restlessness	very rare	—	—	Restlessness	—	—	—	—	—	—	—
Eye Irritation	rare	—	—	Eye irritation	—	—	—	—	—	—	—
Discomfort	—	—	—	Discomfort or irritation	—	—	—	—	discomfort	—	—
Redness	rare	—	—	Discomfort/redness	—	—	—	—	—	—	—
Rhinitis Medicamentosa	—	—	—	Rhinitis medicamentosa	—	—	—	—	—	—	—
Allergic Reactions	rare	—	—	—	—	allergic reactions	Allergic reactions	—	—	Allergic reactions	—
Rash	—	—	—	—	—	rash	—	—	—	—	—
Hives	—	—	—	—	—	hives	—	—	—	—	—
Trouble Breathing	—	—	—	—	—	trouble breathing	—	—	—	—	—
Swelling	—	—	—	—	—	swelling of the face, lips, or throat	—	—	swelling	—	—
Fainting	—	—	—	—	—	—	fainting	—	fainting	—	—
Vomiting	—	—	—	—	—	—	vomiting	—	vomiting	—	—
Nosebleeds	—	—	—	—	—	—	nosebleeds	—	—	—	—
Irritation	common	—	—	—	—	—	irritation	—	—	—	—
Cardiac Arrhythmia	—	—	—	—	—	—	—	Cardiac arrhythmia	—	—	cardiac irregularities
Hypertension	—	—	—	—	—	—	—	Hypertension	—	—	hypertension
Low Blood Pressure	—	—	—	—	—	—	low blood pressure	—	low blood pressure	—	—
Abnormally Slow Breathing	—	—	—	—	—	—	—	—	abnormally slow breathing	—	—
Fetal Kidney Abnormalities	—	—	—	—	—	—	—	—	fetal kidney abnormalities	—	—
Changes in Fetal Heart Rate	—	—	—	—	—	—	—	—	changes in fetal heart rate	—	—
Ulceration	—	ulceration	—	—	—	—	—	—	—	—	ulceration of nasal mucosa
Necrosis	—	necrosis	—	—	—	—	—	—	—	—	—
Ischemic Changes	—	ischemic changes	—	—	—	—	—	—	—	—	—
Arterial Thrombosis	—	arterial thrombosis	—	—	—	—	—	—	—	—	—
PNL Accumulations	—	PNL accumulations	—	—	—	—	—	—	—	—	—
Focal Inflammation	—	focal inflammation	—	—	—	—	—	—	—	—	—
Lymphocyte Aggregation	—	lymphocyte aggregation	—	—	—	—	—	—	—	—	—
Periductal Inflammation	—	periductal inflammation	—	—	—	—	—	—	—	—	—
Blurred Vision	—	—	—	Blurred vision	Blurred vision	—	—	—	—	—	—
Lightheadedness	—	—	—	lightheadedness	lightheadedness	—	—	—	—	—	—
Drowsiness	—	—	—	drowsiness	drowsiness	—	—	—	—	—	—
Weakness	—	—	—	weakness	weakness	—	—	—	—	—	weakness
Palpitations	very rare	—	—	Palpitations	—	—	—	Palpitations	—	—	—
Tachycardia	very rare	—	—	Tachycardia	—	—	—	—	—	—	—
Urination Trouble	—	—	—	—	Urination trouble	—	—	—	—	—	—

Demographic risk groups

Group	Risk	Sources
rats	experimental model	PubMed Central
male Wistar Albino rats	12-16 weeks old, 200-240 gr	PubMed Central
children	sensitive to the effects of oxymetazoline	MedlinePlus, Mayo Clinic, WebMD, Poison.org, My.clevelandclinic.org, Oacapps.med.jhmi.edu
children 6 to 12 years of age	higher risk	MedlinePlus
pregnant	vasoconstriction of uterine vessels	MedlinePlus, Drugs.com, WebMD, Healio.com, My.clevelandclinic.org
patients with high blood pressure	May worsen condition	MedlinePlus, Mayo Clinic
patients with diabetes	higher risk	MedlinePlus
patients with heart disease	higher risk	MedlinePlus
elderly	different side effects or problems	Mayo Clinic, Healio.com
breastfeeding	infant risk	Mayo Clinic, WebMD
Patients with dryness in nose	May worsen condition	Mayo Clinic
Patients with tachycardia	May worsen condition	Mayo Clinic
Patients with enlarged prostate	May worsen urination trouble	Mayo Clinic
Children up to 6 years of age	Dose must be determined by doctor	Mayo Clinic
diabetes	caution	WebMD
heart disease	caution	WebMD, Oacapps.med.jhmi.edu
high blood pressure	caution	WebMD
thyroid problems	caution	WebMD
enlarged prostate	caution	WebMD
infants	age restriction	WebMD
Hypertension patients	Higher risk of raised blood pressure	GoodRx
Lactation	insufficient human data	Healio.com
Pediatric	precaution	Healio.com
seniors	higher risk of side effects	Poison.org
young children	more likely to experience side effects	Poison.org
children less than six years of age	should not be used	Poison.org
pregnant women	harm to the fetus	Poison.org
breast-feeding	caution	My.clevelandclinic.org
pregnancy	category C	Oacapps.med.jhmi.edu
hyperthyroidism		Oacapps.med.jhmi.edu
hypertension		Oacapps.med.jhmi.edu
diabetes mellitus		Oacapps.med.jhmi.edu