Anastrozole Side Effects — Compared Across 6 Medical Sources

This tool aggregates publicly available information for reference only. It is not medical advice. Always consult a healthcare professional before making decisions about medication.

77 side effects

Side effect	Frequency	MedlinePlus	Mayo Clinic	Breastcancernow.org	NHS	GoodRx	Breastcancer.org
Nausea	common	nausea	nausea	Nausea and vomiting	Feeling or being sick	Nausea	nausea
Headache	—	headache	Headache	Headaches	—	Headaches	headache
Hot flashes	common	hot flashes	—	Hot flushes	Hot flushes	Hot flashes	hot flashes
Vomiting	common	vomiting	vomiting	Nausea and vomiting	—	Vomiting	vomiting
Diarrhea	—	diarrhea	diarrhea	Diarrhoea and constipation	—	—	—
Constipation	—	constipation	Constipation	Diarrhoea and constipation	—	—	—
Loss of appetite	—	loss of appetite	Loss of appetite	Loss of appetite, indigestion and heartburn	Losing appetite	—	—
Stomach pain	common	stomach pain	Stomach pain	—	—	Upset stomach	—
Dizziness	—	dizziness	Dizziness	Dizziness	—	—	—
Mood changes	—	mood changes	—	Low mood and depression	Low mood	Mood changes	—
Depression	—	depression	Depression	Low mood and depression	—	—	depression
Insomnia	—	difficulty falling asleep or staying asleep	Insomnia	Difficulty sleeping	Difficulty sleeping	Insomnia	insomnia
Nervousness	—	nervousness	Nervousness	—	—	—	—
Vaginal bleeding	—	vaginal bleeding	Vaginal bleeding	Vaginal bleeding	Vaginal bleeding	Vaginal bleeding	—
Vaginal dryness	—	vaginal dryness or irritation	—	Vaginal irritation	Dry or itchy vagina	Vaginal dryness	—
Joint pain	—	joint, bone, or muscle pain	Joint pain	Aching or pain in the joints and muscles	Mild aches in muscles and bones	Muscle, joint, and bone pain	joint pain
Muscle pain	common	joint, bone, or muscle pain	Muscle weakness	Aching or pain in the joints and muscles	weak muscles	Muscle and joint pain	—
Bone pain	—	joint, bone, or muscle pain	Bone pain	Aching or pain in the joints and muscles	—	Muscle, joint, and bone pain	—
Osteoporosis	—	osteoporosis	Osteoporosis	Osteoporosis	osteoporosis	Weaker bones (osteoporosis)	osteoporosis
Fatigue	common	—	—	Extreme tiredness	Tiredness	Fatigue	—
Weight gain	—	weight gain	—	—	—	—	—
Weight loss	—	—	Weight loss	—	—	Weight loss	—
High cholesterol	—	—	High cholesterol	High cholesterol	increased cholesterol levels	High cholesterol	high cholesterol
Heart problems	—	—	Heart problems	—	—	Heart problems	heart problems
Chest pain	—	chest pain	Chest pain	Pain in arm or leg	—	Chest pain	chest pain
Shortness of breath	—	shortness of breath	Shortness of breath	Shortness of breath	—	Shortness of breath	—
Sore throat	—	sore throat	Sore throat	—	—	—	sore throat
Cough	uncommon	cough	Cough	—	—	Dry cough	—
Fever	uncommon	fever	Fever	—	—	—	—
Chills	uncommon	chills	Chills	—	—	—	—
Swollen glands	—	swollen glands	—	—	—	—	—
Infection	—	infection	—	—	—	—	—
Swelling	—	swelling	Swelling of the feet or lower legs	—	—	Swelling	—
Redness	—	redness	—	Redness/discolouration of skin	—	—	—
Warmth	—	warmth	—	Heat and swelling of arm or leg	—	—	—
Difficult urination	—	difficult urination	Difficult urination	—	—	—	—
Painful urination	—	painful urination	—	—	—	—	—
Urgent urination	—	urgent urination	—	—	—	—	—
Blurred vision	—	blurred vision	Blurred vision	—	—	—	—
Vision changes	—	vision changes	—	—	—	—	—
Yellowing of the skin or eyes	—	yellowing of the skin or eyes	Yellow eyes and skin	—	—	—	—
Skin lesions	—	skin lesions	Skin lesions	Skin changes	Changes to skin	—	—
Ulcers	—	ulcers	Ulcers	—	—	—	—
Blisters	—	blisters	Blisters	—	—	—	—
Rash	common	rash	Rash	Skin rash	—	—	rash
Hives	—	hives	Hives	—	—	—	—
Itching	—	itching	Itching	—	Dry or itchy vagina	—	—
Anaphylaxis	rare	—	Anaphylaxis	—	anaphylaxis	—	—
Angioedema	—	—	Angioedema	—	—	—	—
Heart attack	—	—	Heart attack	—	heart attack	heart attacks	—
Stroke	—	—	—	—	stroke	—	—
Blood clots	—	—	—	Blood clots	—	—	—
Pounding in the ears	—	—	Pounding in the ears	—	—	—	—
Slow or fast heartbeat	—	—	Slow or fast heartbeat	—	—	—	—
Puffiness or swelling	—	—	Puffiness or swelling	—	—	—	—
Metallic taste	—	—	Metallic taste	—	—	—	—
Thirst	—	—	Thirst	—	thirst and frequent urination	—	—
Dry mouth	—	dry mouth	Dry mouth	—	—	—	—
Hair loss	—	hair thinning	—	Hair loss	Hair loss	—	—
Facial hair increase	—	—	—	Facial hair increase	—	—	—
Skin changes	—	—	—	Skin changes	Changes to skin	—	—
Liver problems	—	—	—	Changes to the liver	liver problems	—	—
Henoch-Schönlein purpura	—	—	—	—	Henoch-Schönlein purpura	—	—
Anxiety	—	—	—	—	—	—	Anxiety
Back pain	—	—	Back pain	—	—	—	back pain
Arm pain	—	—	Arm pain	Pain in arm or leg	—	—	—
Leg pain	—	—	Pain in foot or leg	Pain in arm or leg	—	—	—
Foot pain	—	—	Pain in foot or leg	—	—	—	—
Hand pain	—	—	—	—	—	—	—
Morning stiffness	common	—	—	—	—	Morning stiffness	—
Lightheadedness	—	—	—	—	—	Lightheadedness	—
Dry cough	—	—	—	—	—	Dry cough	—
Bone thinning	common	—	—	—	—	Bone thinning	—
Broken bones	—	—	—	—	—	—	Broken bones
Reduced libido	—	—	—	Reduced libido	—	—	—
Night sweats	—	—	—	Night sweats	—	—	—
Carpal tunnel syndrome	—	—	—	Carpal tunnel syndrome	—	—	—

1 additional sourcedidn't return structured side-effect data: Singlecare.com.

Demographic risk groups

Group	Risk	Sources
women who have undergone menopause	should only be taken	MedlinePlus
pregnant women	may cause damage to developing embryos and pregnancy loss	MedlinePlus, Breastcancer.org
breast-feeding women	should tell doctor	MedlinePlus
children	pediatric-specific problems	MedlinePlus, Mayo Clinic, NHS
elderly	geriatric-specific problems	Mayo Clinic
breastfeeding women	infant risk	Mayo Clinic
premenopausal women	should not be used	Mayo Clinic
patients with bone problems	may make these conditions worse	Mayo Clinic
patients with hypercholesterolemia	may make these conditions worse	Mayo Clinic
patients with ischemic heart disease	may make these conditions worse	Mayo Clinic
patients with liver disease	use with caution	Mayo Clinic
Postmenopausal women	Pregnancy	Mayo Clinic
Women with history of ischemic heart disease	Heart problems	Mayo Clinic
Women	Higher risk of high cholesterol	Breastcancernow.org, GoodRx
People with breast cancer	Higher risk of blood clots	Breastcancernow.org
people with black or brown skin	difficulty identifying symptoms	NHS
women who have gone through menopause	higher risk	GoodRx
People with early-stage breast cancer	Higher risk of joint problems	GoodRx
men	reduced sex drive	GoodRx
patients with a history of heart problems	higher risk of heart problems	GoodRx
post-menopausal women	higher risk of side effects	Breastcancer.org
women with heart disease	may increase the risk of heart problems	Breastcancer.org
women with osteopenia or osteoporosis	may lead to bone thinning and weakening	Breastcancer.org