Ibuprofen Side Effects — Compared Across 8 Medical Sources

108 side effects

Side effect	Frequency	MedlinePlus	FDA	WebMD	RxList	Adf.org.au	HSS	Genesishcs.org	GoodRx
Nausea	common	nausea	—	—	nausea	nausea	—	—	nausea
Headache	common	—	—	—	headache	headache	—	—	—
Dizziness	common	dizziness	—	—	dizziness	dizziness	dizziness	—	—
Drowsiness	common	—	—	—	—	drowsiness	—	—	—
Fatigue	common	—	—	—	—	fatigue	—	—	—
Restless sleep	common	—	—	—	—	restless sleep	—	—	—
Thirst	common	—	—	—	—	thirst	—	—	—
Sweating	common	—	—	—	—	sweating	—	—	—
Tingling	common	—	—	—	—	tingling	—	—	—
Numbness	common	—	—	—	—	numbness	—	—	—
Ringing in the ears	common	ringing in the ears	—	—	ringing in the ears	ringing in the ears	ringing in the ears	—	—
Blurred vision	common	—	—	—	blurred vision	blurred vision	—	—	—
Eye irritation	common	—	—	—	—	eye irritation	—	—	—
Fluid retention	common	—	—	—	fluid retention	fluid retention	fluid retention	—	—
Ankle swelling	common	—	—	—	—	ankle swelling	—	—	—
Mild allergic reaction	common	—	—	—	—	mild allergic reaction	—	—	—
Abdominal pain	common	stomach pain	—	—	upper stomach pain	abdominal pain	abdominal pain	—	stomach pain
Vomiting	common	vomit that is bloody	vomit blood	—	vomiting	vomiting	—	—	unexplained vomiting
Heartburn	very common	heartburn	heartburn	heartburn	heartburn	heartburn	heart burn	Heartburn	—
Diarrhea	common	diarrhea	—	—	diarrhea	diarrhoea	—	—	—
Constipation	common	constipation	—	—	constipation	constipation	—	—	—
Bladder irritation	common	—	—	—	—	bladder irritation	—	—	—
Frequent urination	common	—	—	—	—	frequent urination	—	—	—
Heart attack	—	heart attack	—	heart attack	heart attack	heart attack	heart attack	Increased risk of heart attack	Heart attack
Stroke	—	stroke	—	stroke	stroke	stroke	stroke	—	Stroke
Confusion	—	—	—	—	—	confusion	confusion	—	—
Disorientation	—	—	—	—	—	disorientation	—	—	—
Anxiety	—	—	—	—	—	anxiety	—	—	—
Paranoia	—	—	—	—	—	paranoia	—	—	—
Anemia	—	—	—	—	—	anaemia	—	Anemia	—
Tinnitus	—	—	—	—	—	tinnitus	—	—	—
Seizures	—	—	—	—	seizures	seizures	—	—	—
Coma	—	—	—	—	coma	coma	—	—	—
Death	—	serious side effects or death	—	—	—	death	—	—	—
Impaired hearing	—	—	—	—	—	impaired hearing	decreased hearing	Impaired hearing	—
Kidney damage	—	—	—	—	kidney damage	kidney damage	kidney problems	Kidney damage	kidney problems
Liver damage	rare	—	—	—	liver damage	liver damage	liver injury	Liver damage	liver problems
Stomach bleeding	—	bleeding	stomach bleeding	bleeding	—	stomach bleeding	stomach bleeding	Bleeding in the stomach and bowels	stomach bleeding
Bowel bleeding	—	—	—	—	—	bowel bleeding	—	Bleeding in the stomach and bowels	—
Stomach irritation	very common	—	—	—	—	stomach irritation	stomach irritation	—	—
Gastrointestinal problems	common	—	—	—	—	—	gastrointestinal problems	Gastrointestinal symptoms	—
Cardiovascular side effects	—	—	—	—	—	—	cardiovascular side effects	—	—
Ulcer development	—	—	—	—	—	—	ulcer development	—	—
Reflux	very common	—	—	—	—	—	reflux	—	—
Internal bleeding	rare	—	—	—	—	—	internal bleeding	Internal bleeding	—
Perforation	very rare	—	—	—	—	—	perforation	—	—
Black, tarry stool	—	black and tarry stools	bloody or black stools	—	black, tarry stool	—	black, tarry stool	—	dark-colored stools
Bleeding	—	bleeding	—	bleeding	—	—	bleeding	—	—
Ulceration	—	—	—	—	—	—	ulceration	—	—
Myocardial infarction	—	—	—	—	—	—	myocardial infarction	—	—
Bleeding problem	—	—	bleeding problems	—	—	—	bleeding problem	—	—
High blood pressure	—	—	—	—	—	—	high blood pressure	—	High blood pressure
Diabetes	—	—	—	—	—	—	diabetes	—	—
GI risk	—	—	—	—	—	—	GI risk	—	—
Cardiovascular risk	—	—	—	—	—	—	cardiovascular risk	—	—
Kidney function problems	—	—	—	—	—	—	kidney function problems	—	—
Heart issues	—	—	—	—	—	—	heart issues	—	—
Miscarriage	—	—	—	—	—	—	miscarriage	—	—
Allergic reaction	—	—	—	—	—	allergic reaction	allergic reaction	—	—
Skin rash	—	redness or swelling	rash	—	skin rash	—	skin rash	—	—
Allergy	—	—	—	—	—	—	allergy	—	—
Vision abnormalities	—	—	—	—	—	—	vision abnormalities	—	—
Depression	—	—	—	—	depression	—	depression	—	—
Liver injury	rare	—	—	—	—	—	liver injury	—	—
Kidney problems	—	—	—	—	—	—	kidney problems	—	kidney problems
Decreased hearing	—	—	—	—	—	—	decreased hearing	—	—
Hives	—	—	hives	—	hives	—	—	—	—
Facial swelling	—	—	facial swelling	—	facial swelling	—	—	—	—
Shock	—	—	shock	—	—	—	shock	—	—
Skin reddening	—	—	skin reddening	—	—	—	—	—	—
Rash	—	—	rash	—	rash	—	rash	—	—
Blister	—	—	blister	—	blisters	—	blisters	—	—
Bloating	common	gas or bloating	—	—	bloating	—	—	—	—
Gas	common	gas or bloating	—	—	gas	—	—	—	—
Unexplained weight gain	—	unexplained weight gain	—	—	rapid weight gain	—	—	—	—
Shortness of breath	—	shortness of breath	—	—	shortness of breath	—	—	—	—
Weakness in one part or side of the body	—	weakness in one part or side of the body	—	—	—	—	—	—	—
Slurred speech	—	slurred speech	—	—	—	—	—	—	—
Chest pain	—	chest pain	—	—	—	—	—	—	—
Swelling of the abdomen, feet, ankles, or lower legs	—	swelling of the abdomen, feet, ankles, or lower legs	—	—	swelling	—	—	—	—
Fever, rash, blisters	—	fever, rash, blisters	—	—	fever, rash, blisters	—	—	—	—
Overdose	—	overdose	—	—	—	—	—	—	—
Redness or swelling	—	redness or swelling	—	—	—	—	—	—	—
New or unexpected symptoms	—	new or unexpected symptoms	—	—	—	—	—	—	—
Vision changes	—	—	—	—	vision changes	—	—	—	—
Rapid weight gain	—	—	—	—	rapid weight gain	—	—	—	—
Nervousness	common	nervousness	—	—	nervousness	—	—	—	—
Itching	—	—	—	—	itching	—	—	—	—
Feeling tired	—	—	—	—	feeling tired	—	—	—	—
Flu-like symptoms	—	—	—	—	flu-like symptoms	—	—	—	—
Loss of appetite	—	—	—	—	loss of appetite	—	—	—	—
Little or no urinating	—	—	—	—	little or no urinating	—	—	—	—
Dark urine	—	—	—	—	dark urine	—	—	—	—
Clay colored stools	—	—	—	—	clay colored stools	—	—	—	—
Jaundice	—	—	—	—	jaundice	—	—	—	—
Rapid heart rate	—	—	—	—	rapid heart rate	—	—	—	—
Trouble concentrating	—	—	—	—	trouble concentrating	—	—	—	—
Burnning in eyes	—	—	—	—	burnning in eyes	—	—	—	—
Vomit that is bloody	—	vomit that is bloody	vomit blood	—	coughing up blood	—	—	—	—
Blood in the stool	—	blood in the stool	—	—	—	—	—	—	blood in vomit or stool
Stomach upset	—	stomach upset	upset stomach	—	—	—	—	—	—
Ulcers in the esophagus	—	holes in the esophagus	—	—	—	—	—	—	—
Ulcers in the stomach	—	holes in the stomach	—	—	—	—	—	—	—
Ulcers in the intestine	—	holes in the intestine	—	—	—	—	—	—	—
Stomach ulcers	uncommon	ulcers	ulcers	stomach ulcers	—	—	ulcer	Ulcers	stomach ulcers
Bleeding problems	—	—	bleeding problems	—	—	—	—	—	—
Serious side effects or death	—	serious side effects or death	—	—	—	—	—	—	—
Asthma	—	—	—	—	asthma	—	—	—	—

7 additional sourcesdidn't return structured side-effect data: Mayo Clinic, Drugs.com, NHS, Cleveland Clinic, News-medical.net, Healthdirect.gov.au, Medical News Today.

Demographic risk groups

Group	Risk	Sources
older adults	higher risk of ulcers, bleeding, or holes in the esophagus, stomach, or intestine	MedlinePlus, GoodRx
people with poor health	higher risk of ulcers, bleeding, or holes in the esophagus, stomach, or intestine	MedlinePlus
smokers	higher risk of ulcers, bleeding, or holes in the esophagus, stomach, or intestine	MedlinePlus
people who drink large amounts of alcohol	higher risk of ulcers, bleeding, or holes in the esophagus, stomach, or intestine	MedlinePlus
young children	serious side effects or death	MedlinePlus
children younger than 4 years of age	serious side effects or death	MedlinePlus
children 4 to 11 years of age	serious side effects	MedlinePlus
children	safe use not established	MedlinePlus, FDA, WebMD, RxList
elderly	higher risk	MedlinePlus, GoodRx
pregnant	problems in the unborn child or complications during delivery	MedlinePlus, FDA, HSS
renal impairment	kidney disease	MedlinePlus
liver disease	liver disease	MedlinePlus
people allergic to aspirin	severe allergic reaction	FDA
age 60 or older	higher chance of stomach bleeding	FDA
people aged 60 years and older	greater risk for some side effects	WebMD
pregnant women	may cause problems in unborn child or complications during delivery	WebMD, RxList, HSS
breastfeeding women	ibuprofen passes into breast milk	WebMD
people with kidney problems	unknown	WebMD
people with liver problems	Higher risk of stomach bleeding	WebMD, GoodRx
breast-feeding women	may harm nursing baby	RxList
people 60 or older	higher chance of stomach bleeding	RxList
people with stomach ulcers or bleeding problems	higher chance of stomach bleeding	RxList
people taking blood thinning or steroid drugs	higher chance of stomach bleeding	RxList
people taking other NSAIDs	higher chance of stomach bleeding	RxList
people with high blood pressure, heart disease, liver cirrhosis, or kidney disease	higher risk of side effects	RxList
people with asthma	higher risk of side effects	RxList
people with heart disease	increased risk of heart attack or stroke	Adf.org.au
elderly patients	greater risk for serious GI events	HSS
patients with a prior history of peptic ulcer disease	greater risk for serious GI events	HSS
patients with GI bleeding	greater risk for serious GI events	HSS
patients at high risk for cardiovascular disease	need to weigh the risks and benefits	HSS
older people	increased GI and cardiovascular risk	HSS
people with abnormal kidney function	negative effect on kidney function	HSS
women having difficulty conceiving	NSAIDs may affect ability to become pregnant	HSS
patients with kidney problems	higher risk	GoodRx
patients with heart problems	higher risk	GoodRx
patients with liver problems	higher risk	GoodRx
patients with bleeding problems	higher risk	GoodRx
breastfeeding patients	unknown	GoodRx
patients allergic to aspirin	unknown	GoodRx
People with heart problems	Higher risk of heart attack and stroke	GoodRx
People with history of stomach bleeding or ulcers	Higher risk of stomach bleeding	GoodRx
People taking other medications that raise risk of bleeds	Higher risk of stomach bleeding	GoodRx
People drinking alcohol	Higher risk of stomach bleeding	GoodRx