| Nausea | common | nausea | Nausea | Feeling or being sick | Nausea | nausea | nausea |
| Vomiting | common | vomiting | Vomiting | Feeling or being sick | Vomiting | vomiting | vomiting |
| Diarrhea | common | — | Diarrhea | Diarrhoea | — | diarrhea | — |
| Headache | common | — | Headache | Headaches | Headaches | — | — |
| Fatigue | common | fatigue | Unusual tiredness or weakness | Feeling tired or drowsy | Fatigue | — | fatigue |
| Hair loss | common | alopecia | Hair loss | Hair loss | Hair loss | hair loss | hair loss |
| Liver problems | rare | liver disease | — | liver problems | — | liver issues | liver toxicity |
| Infection | rare | infection | — | infection | — | infection | — |
| Blood disorder | rare | — | — | blood disorder | — | — | — |
| Allergic reaction | rare | Hypersensitivity reactions | — | allergic reaction | — | — | — |
| Gastrointestinal upset | common | gastrointestinal toxicity | — | — | — | gastrointestinal upset | stomach upset |
| Mouth sores | common | mucosal ulcers | Sores in the mouth or lips | — | Mouth ulcers | mouth sores | mouth sores |
| Rash | common | — | Itching, rash, reddening of the skin | — | — | rash | skin rash |
| Dizziness | uncommon | dizziness | Dizziness | — | — | dizziness | dizziness |
| Abnormalities in blood counts | uncommon | low white blood cell count | — | — | Drop in white blood cells | abnormalities in blood counts | drop in white blood cell count |
| Mucosal ulcers | common | mucosal ulcers | — | — | — | — | — |
| Loss of appetite | common | loss of appetite | Loss of appetite | Loss of appetite | — | — | — |
| Hepatotoxicity | uncommon | hepatotoxicity | — | — | — | — | — |
| Alopecia | — | alopecia | — | — | — | — | — |
| Fever | uncommon | fever | Fever or chills | — | — | — | fever |
| Increased risk of infection | — | increased risk of infection | — | — | — | — | — |
| Low white blood cell count | — | low white blood cell count | — | — | — | — | — |
| Gastrointestinal bleeding | — | gastrointestinal bleeding | — | — | — | — | — |
| Pancreatitis | — | pancreatitis | — | — | — | — | — |
| Bone marrow suppression | — | bone marrow suppression | — | — | — | — | — |
| Malignancy | — | malignancy | — | — | — | — | — |
| Renal failure | — | renal failure | — | — | — | — | — |
| Embryo-fetal toxicity | — | Embryo-fetal toxicity | — | — | — | — | — |
| Hypersensitivity reactions | — | Hypersensitivity reactions | — | — | — | — | — |
| Organ damage | — | Organ damage | — | — | — | — | — |
| Fatalities | — | Fatalities | — | — | — | — | — |
| Bone marrow toxicity | — | Bone marrow toxicity | — | — | — | — | — |
| Pulmonary toxicity | — | Pulmonary toxicity | — | — | — | — | — |
| Dry cough | — | Dry cough | — | — | — | — | — |
| Dyspnea | — | Dyspnea | — | — | — | — | — |
| Reactivation of tuberculosis | — | Reactivation of tuberculosis | — | — | — | — | — |
| Mucosal ulceration | — | mucosal ulceration | — | — | — | — | — |
| Leukopenia | — | leukopenia | — | — | — | — | — |
| GI bleeding | — | GI bleeding | — | — | — | — | — |
| Aplastic anemia | — | aplastic anemia | — | — | — | — | — |
| Interstitial pneumonitis | — | interstitial pneumonitis | — | — | — | — | — |
| Renal impairment | — | renal impairment | — | — | — | — | — |
| Teratogenesis | — | teratogenesis | — | — | — | — | — |
| Myelosuppression | — | myelosuppression | — | — | — | — | — |
| Gastrointestinal toxicity | — | gastrointestinal toxicity | — | — | — | — | — |
| Neurotoxicity | — | neurotoxicity | — | — | — | — | — |
| Nephrotoxicity | — | nephrotoxicity | — | — | — | — | — |
| Coughing | — | coughing | — | — | — | — | — |
| Wheezing | — | wheezing | — | — | — | — | — |
| Shortness of breath | — | shortness of breath | — | — | — | — | — |
| Unusual bleeding | common | unusual bleeding | Unusual bleeding or bruising | — | — | — | abnormal bleeding |
| Liver disease | — | liver disease | — | — | — | — | — |
| Teratogenicity | — | teratogenicity | — | — | — | — | — |
| Sun-sensitivity | — | — | — | Sensitivity to sunlight | — | — | sun-sensitivity |
| Liver toxicity | — | — | — | — | — | — | liver toxicity |
| Black stools | common | — | Black, tarry stools | — | — | — | black stools |
| Difficulty breathing | common | — | Trouble breathing | — | — | — | difficulty breathing |
| Yellow eyes or skin | common | — | Yellow eyes or skin | — | — | — | yellow eyes or skin |
| Marked fatigue | — | — | — | — | — | — | marked fatigue |
| Skin rash | — | — | — | — | — | — | skin rash |
| Stomach upset | common | — | — | — | — | — | stomach upset |
| Elevation of liver chemistries | — | — | — | — | — | — | elevation of liver chemistries |
| Abnormal bleeding | — | — | — | — | — | — | abnormal bleeding |
| Methotrexate fog | common | — | — | — | Methotrexate fog | — | — |
| Fibrosis and inflammation in the lungs | — | — | — | — | Fibrosis and inflammation in the lungs | — | — |
| Drop in white blood cells | — | — | — | — | Drop in white blood cells | — | — |
| Dip in production of blood platelets | — | — | — | — | Dip in production of blood platelets | — | — |
| Stomach pain | common | — | Stomach pain | Stomach pain or indigestion | — | — | — |
| Itching | common | — | Itching, rash, reddening of the skin | — | — | — | — |
| Joint pain | common | — | Joint pain | — | — | — | — |
| Trouble breathing | common | — | Trouble breathing | — | — | — | — |
| Swelling | common | — | Swelling of the eyelids, face, lips, hands, feet, or lower legs | — | — | — | — |
| Back pain | uncommon | — | Back pain | — | — | — | — |
| Blurred vision | uncommon | — | Blurred vision | — | — | — | — |
| Body and muscle pain | uncommon | — | Body and muscle pain | — | — | — | — |
| Burning while urinating | uncommon | — | Burning while urinating | — | — | — | — |
| Confusion | uncommon | — | Confusion | — | — | — | — |
| Cough or hoarseness | uncommon | — | Cough or hoarseness | — | — | — | — |
| Cracked, dry, scaly skin | uncommon | — | Cracked, dry, scaly skin | — | — | — | — |
| Dark urine | uncommon | — | Dark urine | — | — | — | — |
| Ear congestion | uncommon | — | Ear congestion | — | — | — | — |
| Loss of hearing | uncommon | — | Loss of hearing | — | — | — | — |
| Loss of voice | uncommon | — | Loss of voice | — | — | — | — |
| Lower back or side pain | uncommon | — | Lower back or side pain | — | — | — | — |
| Painful or difficult urination | uncommon | — | Painful or difficult urination | — | — | — | — |
| Pale skin | uncommon | — | Pale skin | — | — | — | — |
| Runny nose | uncommon | — | Runny nose | — | — | — | — |
| Seizures | uncommon | — | Seizures | — | — | — | — |
| Sneezing | uncommon | — | Sneezing | — | — | — | — |
| Sore throat | uncommon | — | Sore throat | — | — | — | — |
| Stuffy or runny nose | uncommon | — | Stuffy or runny nose | — | — | — | — |
| Unusual tiredness or weakness | uncommon | — | Unusual tiredness or weakness | — | — | — | — |
| Weight loss | uncommon | — | Weight loss | — | — | — | — |
| White or brownish vaginal discharge | uncommon | — | White or brownish vaginal discharge | — | — | — | — |
| Anxiety | — | — | Anxiety | — | — | — | — |
| Blistering, peeling, or loosening of the skin | — | — | Blistering, peeling, or loosening of the skin | — | — | — | — |
| Bloating | — | — | Bloating | — | — | — | — |
| Changes in skin color | — | — | Changes in skin color | — | — | — | — |
| Constipation | — | — | Constipation | — | — | — | — |
| Decreased interest in sexual intercourse | — | — | Decreased interest in sexual intercourse | — | — | — | — |
| Difficulty in moving | — | — | Difficulty in moving | — | — | — | — |
| Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position | — | — | Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position | — | — | — | — |
| Dry mouth | — | — | Dry mouth | — | — | — | — |
| Dryness or soreness of the throat | — | — | Dryness or soreness of the throat | — | — | — | — |
| Eye pain | — | — | Eye pain | — | — | — | — |
| Fruit-like breath odor | — | — | Fruit-like breath odor | — | — | — | — |
| Heartburn | — | — | Heartburn | — | — | — | — |
| Inability to have or keep an erection | — | — | Inability to have or keep an erection | — | — | — | — |
| Increased hunger or thirst | — | — | Increased hunger or thirst | — | — | — | — |
| Indigestion | — | — | Indigestion | — | — | — | — |
| Irritation in the mouth | — | — | Irritation in the mouth | — | — | — | — |
| Large, flat, blue, or purplish patches in the skin | — | — | Large, flat, blue, or purplish patches in the skin | — | — | — | — |
| Loss in sexual ability, desire, drive, or performance | — | — | Loss in sexual ability, desire, drive, or performance | — | — | — | — |
| Loss of consciousness | — | — | Loss of consciousness | — | — | — | — |
| Menstrual problem | — | — | Menstrual problem | — | — | — | — |
| Night blindness | — | — | Night blindness | — | — | — | — |
| Pain in the chest or groin | — | — | Pain in the chest or groin | — | — | — | — |
| Pain, redness, swelling, or tenderness in the arm or leg | — | — | Pain, redness, swelling, or tenderness in the arm or leg | — | — | — | — |
| Red skin lesions, often with a purple center | — | — | Red skin lesions, often with a purple center | — | — | — | — |
| Red, wart-like spots on the skin | — | — | Red, wart-like spots on the skin | — | — | — | — |
| Sudden loss of coordination | — | — | Sudden loss of coordination | — | — | — | — |
| Sudden onset of slurred speech | — | — | Sudden onset of slurred speech | — | — | — | — |
| Swelling or soreness of the breasts | — | — | Swelling or soreness of the breasts | — | — | — | — |
| Swollen, painful, or tender lymph glands in the neck or armpit | — | — | Swollen, painful, or tender lymph glands in the neck or armpit | — | — | — | — |
| Tingling or numbness in the hands, feet, or lips | — | — | Tingling or numbness in the hands, feet, or lips | — | — | — | — |
| Blemishes on the skin | uncommon | — | Blemishes on the skin | — | — | — | — |
| Skin irritation | uncommon | — | Skin irritation | — | — | — | — |
| Pimples | uncommon | — | Pimples | — | — | — | — |
| Black, tarry stools | common | — | Black, tarry stools | — | — | — | — |
| Bleeding gums | common | — | Bleeding gums | — | — | — | — |
| Blood in the urine or stools | common | — | Blood in the urine or stools | — | — | — | — |
| Bloody vomit | common | — | Bloody vomit | — | — | — | — |
| Increased heartbeat | common | — | Increased heartbeat | — | — | — | — |
| Itching, rash, reddening of the skin | common | — | Itching, rash, reddening of the skin | — | — | — | — |
| Pinpoint red spots on the skin | common | — | Pinpoint red spots on the skin | — | — | — | — |
| Sores in the mouth or lips | common | — | Sores in the mouth or lips | — | — | — | — |
| Swelling of the eyelids, face, lips, hands, feet, or lower legs | common | — | Swelling of the eyelids, face, lips, hands, feet, or lower legs | — | — | — | — |
| Swelling or inflammation of the mouth | common | — | Swelling or inflammation of the mouth | — | — | — | — |
| Unusual bleeding or bruising | common | — | Unusual bleeding or bruising | — | — | — | — |
| Bloody nose | uncommon | — | Bloody nose | — | — | — | — |
| Continuing ringing, buzzing, or other unexplained noise in the ears | — | — | — | — | — | — | — |
| Drowsiness | — | — | — | — | — | — | — |
| Fever or chills | — | — | — | — | — | — | — |
| Blurred or change in vision | — | — | Blurred or change in vision | — | — | — | — |