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Ranolazine side effects

Aggregated from 5 medical sources. Not medical advice. Always consult a healthcare professional.

70 side effects

Side effectFrequencyPubMed Central (PMC)Mayo ClinicDrugs.comWebMDCleveland Clinic
Abdominal painuncommon——abdominal pain——
Abnormal touch sensation——Abnormal touch sensationabnormal or decreased touch sensation——
Acid or sour stomach——Acid or sour stomachacid or sour stomach——
Agitation——Agitationagitation——
Allergic reactionsrare———Itching, skin rash, or pale red bumps on the skin called hivesAllergic reactions
Belching——Belchingbelching——
Black tongue——————
Bloating or swelling——Bloating or swellingbloating or swelling of the face, arms, hands, lower legs, or feetSwelling in your feet, ankles, or legs—
Blood in urine——Blood in urineblood in the urine——
Bloody stools——————
Blurred visionuncommon—Blurred visionBlurred vision——
Breathing problems——trouble breathingdifficult or labored breathingBreathing problems or wheezing—
Chest pain——Chest painchest pain or discomfortchest pain/pressure—
Chest tightness——Chest tightnesschest tightness——
Chillsrare—ChillschillsFever or general ill feeling—
Comarare—Comacoma——
Confusion——ConfusionconfusionConfusion—
Constipationcommon——constipationConstipationConstipation
Decrease in frequency of urination——decrease in frequency or amount of urinedecrease in frequency of urinationReduced need to pee—
Decrease in urine volume——decrease in frequency or amount of urinedecrease in urine volume——
Depression——Depressiondepression——
Difficulty having a bowel movement——Difficulty having a bowel movementdifficulty having a bowel movement——
Difficulty passing urine——Difficulty passing urinedifficulty in passing urine [dribbling]——
Difficult breathing——Difficult breathingdifficult or labored breathing——
Dizziness——DizzinessdizzinessDizzinessDizziness
Dizziness when standing——Dizziness when standingdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position——
Dry mouth——Dry mouthdry mouth——
Dyspepsiauncommon——dyspepsia——
Fast heartbeat——fast, pounding, or uneven heartbeatfast, irregular, pounding, or racing heartbeat or pulseRacing heart—
Fainting——FaintingfaintingDizziness, feeling lightheaded, or fainting—
Fever————Fever or general ill feeling—
Flatulenceuncommon——flatulence——
Hallucinations——Hallucinationsseeing, hearing, or feeling things that are not there——
Headache——HeadacheheadacheHeadacheHeadache
Heartburn———heartburn——
Heart rhythm changes—————Heart rhythm changes
Hive-like swellingrare—Hive-like swellinglarge, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organsItching, skin rash, or pale red bumps on the skin called hives—
Hostility——Hostilityhostility——
Indigestion———indigestion——
Irregular heartbeat——Irregular heartbeatfast, irregular, pounding, or racing heartbeat or pulse——
Irritability——Irritabilityirritability——
Itchingrare——itchingItching, skin rash, or pale red bumps on the skin called hives—
Joint pain————Joint pain—
Lack or loss of strength———lack or loss of strength——
Lethargy——Lethargylethargy——
Lightheadedness——LightheadednesslightheadednessDizziness, feeling lightheaded, or fainting—
Loss of appetite——Loss of appetite———
Lower back or side pain——Lower back or side pain———
Muscle twitching——Muscle twitchingmuscle twitching——
Nauseacommon—NauseanauseaNauseaNausea
Painful urination——Painful urinationpainful urination——
Rapid weight gain——Rapid weight gainrapid weight gain——
Reduced need to pee————Reduced need to pee—
Seizures——SeizuresseizuresSeizures—
Sensation of spinning——Sensation of spinningsensation of spinning——
Shakiness——Shakinessshakiness in the legs, arms, hands, or feet——
Slow heartbeat——Slow heartbeatslow or irregular heartbeat——
Stomach cramps————Stomach cramps—
Stomach pain——Stomach painstomach painStomach pain—
Stuporrare—Stuporstupor——
Sweating——Sweatingsweating——
Swelling of the face, fingers, or lower legs——Swelling of the face, fingers, or lower legsbloating or swelling of the face, arms, hands, lower legs, or feetSwelling of the face, lips, mouth, tongue, or throat—
Tingling——Tinglingtingling of the hands or feet——
Trembling——Tremblingtrembling or shaking of the hands or feet——
Trouble breathing——Trouble breathingdifficult or labored breathingDifficulty catching your breath—
Trouble swallowing————Trouble swallowing or throat tightness—
Unusual tiredness——Unusual tirednessunusual tiredness or weaknessWeakness or unusual tiredness—
Unusual weight gain or loss——Unusual weight gain or lossunusual weight gain or loss——
Vomiting——VomitingvomitingNausea or vomiting—
Weakness————Weakness or unusual tiredness—

7 additional sourcesdidn't return structured side-effect data: Flow Therapy, Synapse - Global Drug Intelligence Database, GoodRx, Memorial Sloan Kettering Cancer Center, Healio, BuzzRx, Wikipedia.

Demographic risk groups

GroupRiskSources
patients with impaired hepatic or renal functioncaution must be takenPubMed Central (PMC)
malesincidence of CADPubMed Central (PMC)
femalesincidence of CADPubMed Central (PMC)
pediatricsafety and efficacy not establishedMayo Clinic
geriatricage-related liver, kidney, or heart problemsMayo Clinic
breastfeedingpotential benefits against potential risksMayo Clinic, WebMD
Kidney diseaseMay make these conditions worseMayo Clinic, Cleveland Clinic
Liver cirrhosisShould not be usedMayo Clinic
childrenuse and dose must be determined by doctorMayo Clinic, WebMD, Cleveland Clinic
PregnancyRisk data availableDrugs.com
older peoplehigher risk of QT prolongation and torsade de pointesWebMD
pregnantunknownWebMD
liver problemsconcernWebMD
kidney problemsunknownWebMD
pregnant or trying to get pregnantneed to inform care teamCleveland Clinic
breast-feedingneed to inform care teamCleveland Clinic
liver diseaseneed to inform care teamCleveland Clinic

Medside aggregates publicly available side-effect information for reference only. It is not medical advice. Always consult a healthcare professional before making decisions about medication.

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